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KMID : 1007320100160010016
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Journal of the Korean Society of Menopause
2010 Volume.16 No. 1 p.16 ~ p.22
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The Association between Serum Estradiol Level and Coronary Artery Calcification in Postmenopausal Women: A Preliminary Report
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Jeon Gyun-Ho
Kim Sung-Hoon
Kim So-Ra
Chae Hee-Dong
Kim Chung-Hoon
Kang Byung-Moon
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Abstract
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Objectives: To estimate whether coronary artery calcification in postmenopausal women is associated with serum estradiol level.
Methods: The present study retrospectively examined the clinical records of 162 postmenopausal women who visited the Health Promotion Center for a routine checkup and underwent a multidetector CT scan of the heart. Serum estradiol level, coronary heart disease (CHD) risk factors, current hormone therapy status, and BMD of the lumbar vertebrae and femoral neck were analyzed in women with coronary artery calcium score (CACS) ≥ 100 and ＜ 100.
Results: Compared to women with higher CACS (≥ 100), women with lower CACS (＜ 100) had a significantly higher level of serum estradiol (27.34 ± 2.96 vs. 13.31 ± 1.10 pg/ml, P = 0.030) and lower mean age (57.63 ± 0.44 vs. 61.88 ± 1.90, P = 0.037). Women with CACS ＜ 100 were significantly more likely to have a serum estradiol level greater than 20 pg/ml (42.25 vs. 0 %, P = 0.022) and lower prevalence of hypertension (28.17 vs. 62.50%, P = 0.053, borderline significant). However, multiple logistic regression analysis showed that any factors did not have a significant association with CACS except hypertension (OR 5.831 [95% CI 1.035 to 32.85], P = 0.046).
Conclusion: Serum estradiol level might be associated with the degree of calcification of coronary artery in postmenopausal women.
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KEYWORD
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Estradiol, Coronary artery calcification, Postmenopause, Hormone therapy
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